This textbook on Medicinal Chemistry-I as per PCI syllabus is meant strictly for B.Pharm 4th semester students acquiring degree. Medicinal Chemistry is a fascinating branch of science. The text discusses the fundamental chemical principles used for drug discovery and design. The important aspects involved in the medicinal chemistry have been comprehensively covered in the book. I hope the students of B.Pharm 2nd year studying aspects of medicinal chemistry would be benefitted from this textbook. This textbook contains the basic content as included in the curriculum as well as all the details.